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April 2025
Principal Consultant
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The global DNA vaccine market size is calculated at US$ 553.89 in 2024, grew to US$ 590 million in 2025, and is projected to reach around US$ 1041.68 million by 2034. The market is expanding at a CAGR of 6.52% between 2025 and 2034. The DNA vaccine offers target-specific action, along with enhanced immunity against diseases such as cancer. DNA vaccines can be used to treat infectious diseases in both humans and animals.
A DNA vaccine involves genetically engineered DNA, which is injected into the body, causing the cells to produce an antigen that triggers a protective immunological response. Thus, it stimulates the immune system, offering long-lasting immunity. Due to this effective approach, the development of cancer vaccines is also gaining interest. At the same time, vaccines for influenza and hepatitis are also being developed. Similarly, a TB DNA vaccine has been reported to be synthesized. It contains the HIV-1 p24 protein, which protects against Mycobacterium tuberculosis. Thus, the DNA vaccine is not only used for infectious diseases but also for autoimmune diseases, such as multiple sclerosis.
DNA vaccines, particularly those used for cancer treatment, are preferred because they are effective and have fewer side effects. To overcome the limitations of conventional therapies, The use of AI in these vaccines has shown promising effects. AI focuses on antigen selection, adjuvant identification, epitope prediction, and optimization approaches. Similarly, machine learning and deep learning can be utilized to predict antigenic epitopes, assess immunogenicity, and organize antigens for research purposes. The use of AI technologies for the treatment of cancer patients and the development of new technologies serve a great potential to revolutionize the field of oncology therapy. Thus, with the help of emerging technologies and greater accessibility to the data, we can enhance vaccine design strategies.
Rising Demand for Treatment Options
As the number of diseases increases, so does the demand for effective treatment options. This leads to an increase in demand for DNA vaccines. The advantages of the DNA vaccine cause the hospitals and patients to adopt it. At the same time, technological advancements aid in the development and improvement of vaccines. Along with personalized medicines and immunotherapy, there is a growing demand for genetic engineering, vaccine delivery systems, and gene editing. Furthermore, the increasing number of infectious diseases is driving growing awareness, which in turn is fueling the need for effective solutions. Veterinary diseases also require a DNA vaccine for the treatment of animals. Thus, all these factors collectively drive market growth.
Stability Issues
DNA vaccines require cold storage conditions, such as refrigeration or freezing. If the temperature is not appropriate, its stability may be affected. This, in turn, causes degradation. DNA vaccines are susceptible to temperature fluctuations, light exposure, and humidity. Thus, they must be stored properly. The stability is also affected by the delivery systems used in the vaccine. If it contains a lipidic delivery system, it may cause aggregation, which can hamper its stability and effectiveness.
New Cancer Therapies
The incidence of cancer has caused an increased demand for the development of new cancer treatment options. Thus, various research and development sectors are focusing on using DNA vaccines for the development of new cancer therapies. As a DNA vaccine provides target-specific action, it can be used in personalized cancer treatment options for individual patients. This results in fewer side effects and also increases patient adherence to the treatment. Similarly, cancer immunotherapy can be developed by using a DNA vaccine. Cancer immunotherapy eradicates the cancer by enhancing the immune system.
For instance,
By product type, the Oncept segment dominated the market in 2024. Oncept has been widely used in veterinary oncology to treat the increased rates of melanoma. The increased rates of other cancers, such as canine cancer, were also treated using Oncept. This caused the growth of the DNA vaccine market.
By product type, the Apex-IHN segment is estimated to grow significantly at a notable CAGR during the forecast period. The incidence of viral infections in aquaculture is continuously increasing, resulting in a growing demand for Apex-IHN. Thus, it helps reduce mortality rates and aids in the management of viral infections.
By vaccine type, the prophylactic vaccines segment dominated the market in 2024. They provided specific immunity to a large number of the population. At the same time, it was used in both humans and animals. Thus, along with these advantages, the safe and effective use of the vaccine enhanced the market growth.
By vaccine type, the therapeutic vaccine segment is expected to be the fastest-growing during the forecast period. Therapeutic vaccines can be used in the treatment of viral infections and cancer. Their use in immune-oncology is rapidly increasing due to the target-specific action and can be used in personalized cancer treatment.
By therapeutic indications type, the vector-borne diseases segment dominated the market in 2024. The increased rates of vector-borne diseases such as malaria, dengue, and zika caused several infections leading to death. This led to an increased demand for DNA vaccines, as traditional methods were found to be ineffective.
The graph estimates the number of new cases and deaths from vector-borne diseases globally. This suggests that as the number of patients increases, the demand for treatment options will also rise. Furthermore, researchers can focus on developing more effective treatment options, which will ultimately drive the market's growth.
By therapeutic indication type, the cancer segment is expected to be the fastest-growing during the forecast period. DNA vaccines play a significant role in cancer treatment as they stimulate the immune system to fight against cancer cells. They are also being used as personalized medicines for the effective management and treatment of cancer.
By application area type, the human DNA vaccines segment dominated the market in 2024. Human DNA vaccines have shown promise as safe and effective treatments, offering the benefit of personalized medications. This increased interest in healthcare systems has led to a rise in demand for human DNA vaccines in the DNA vaccine market.
By application area type, the animal DNA vaccines segment is estimated to be significantly growing during the forecast period. The increasing prevalence of infectious diseases in animals has led to a growing demand for effective vaccines. Thus, to prove safe and effective vaccines and to control diseases, the demand for animal DNA vaccines is constantly increasing in the market.
By end user, the hospital segment dominated the global DNA vaccine market in 2024. Hospitals provided advanced treatment options to patients by making DNA vaccines available for their use. The specialized staff also used these vaccines to treat the high-risk patients, which decreased the mortality rate. Various vaccination programs conducted by the hospital also attracted the population, contributing to market growth.
By end user, the academic institutes and research organizations segment is predicted to grow significantly during the forecast period. The growing interest in DNA vaccines has spurred innovation and development across various sectors. The collaboration between the companies and the government support is also enhancing the vaccine development process. All these factors contribute to the market's growth.
North America dominated the DNA vaccine market in 2024. North America is home to well-established healthcare systems that have focused on various biotechnological advances. The research and development sectors are also investing in the development of new vaccines to deal with diseases. These advancements collectively contributed to market growth.
The research and development sectors are continuously working on the development of innovative vaccines. The government and private agencies are also investing in these sectors to make different advanced genetic vaccines. The increasing number of diseases has increased their demand in the market. This results in adopting new vaccines.
Different pharmaceutical and biotechnological companies are collaborating to formulate new and advanced vaccines in Canada. At the same time, various research institutes are collaborating with the research sector to make effective contributions to understanding and developing these vaccines.
Asia Pacific is estimated to host the fastest-growing DNA vaccine market during the forecast period. Various countries are demonstrating technological advancements in the biotechnological industry. This causes Asia Pacific to focus on the development and adoption of vaccines. Furthermore, increasing infections lead to a higher demand for vaccines in the market.
The research and development departments in China continue to show advancements in the biotechnology industry. To support them, the government is also making investment that further helps in the process of vaccine development. This, in turn, smoothens the manufacturing process. All these factors contribute to market growth.
India has one of the largest manufacturing units, which has contributed to the rapid development of approved vaccines. At the same time, vaccines are made available to a large number of the population at affordable prices. Research institutes are also making advances in formulating new vaccines with the help of government support. All this results in increased demand for vaccines in the market.
Europe is expected to experience significant growth in the DNA vaccine market during the forecast period. The research and development sectors of Europe play a major role in the market. It focuses on the innovation of DNA vaccines, particularly in areas like personalized medicine and gene therapies. Some research institutes have also shown their interest in the same.
Germany boasts a well-developed biotech and pharmaceutical industry. Due to this, the manufacturing of vaccines is efficiently carried out on a large scale. At the same time, companies are also focusing on developing new vaccines. They are mostly focused on the production of personalized vaccines that use DNA vaccines.
Significant contributions are being made by the UK in the development of various vaccines, including those used for COVID-19. This has increased the interest of research institutes in exploring and developing innovative vaccines for various diseases. To support them, funding is also provided by the government.
By Type of Product
By Type of Vaccine
By Type of Therapeutic Indications
By Application Area
By End User
By Region
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