Towards Healthcare
Gene Expression Market Size, Trends & 5.04% CAGR by 2034

Gene Expression Market Size to Attain USD 25.26 Bn by 2034

Gene expression involves converting genetic information into functional RNA or proteins, vital in healthcare for disease insights and drug discovery. North America leads the market, driven by funding and advancements, while Asia-Pacific grows rapidly with government support and biopharma innovations.

The global gene expression market size is calculated at USD 15.45 billion in 2024, grew to USD 16.23 billion in 2025, and is projected to reach around USD 25.26 billion by 2034. The market is expanding at a CAGR of 5.04% between 2024 and 2034. The rising incidences of chronic disorders, growing genomics & proteomics research, and technological advancements drive the market.

Gene Expression Market Size 2023 - 2034

Unlock Infinite Advantages: Subscribe to Annual Membership

Gene Expression Market: Decoding Protein Synthesis

Gene expression is a process through which information encoded in a gene becomes a function. Two types of products can be obtained through gene expression: RNA molecules that code for proteins and non-coding RNA molecules that serve other functions. Gene expression primarily involves two steps including, transcription and translation. Transcription is a process in which DNA molecules are converted into mRNA, while translation is the process in which mRNA molecules are further converted into proteins.

Gene expression has diverse applications in the healthcare sector. It is used to identify the molecular signature of the disease. It also guides drug discovery by determining the cellular pathways or networks involved in the disease. Additionally, it can be used to mass-produce insulin, human growth hormones, human albumin, monoclonal antibodies, etc. The rising incidences and prevalence of chronic disorders necessitate research and development activities involving the development of novel drugs for treating such disorders. The growing genomics and proteomics research favors market growth. Additionally, increasing investments and favorable government support for genomics and proteomics boost the market.

  • In October 2024, CAMP4 Therapeutics Company announced a research collaboration with BioMarin Pharmaceutical Inc. to advance novel therapeutics that increase protein levels by targeting regulatory RNA (regRNA) sequences, which are key elements controlling gene expression.
  • In March 2024, Patient Square Capital, a healthcare investment firm, acquired NanoString Technologies for $220 million. The acquisition will long-term availability of NanoString Technologies’ leading-edge platforms for spatial biology and gene expression.
  • In March 2023, Chroma Medicine, Inc., a genomic medicine company, announced that it raised $135 million in Series B funding to support the advancement of Chroma’s therapeutic programs and continued investment in the company’s epigenetic editing platform to regulate gene expression.

How Can AI Improve the Gene Expression Market?

Artificial intelligence (AI) can revolutionize gene expression methods and improve the outcomes. Several researchers have investigated the role of AI in gene expression. Integrating AI and machine learning (ML) algorithms supports the development of enhanced systems. This aids in a deeper understanding of the disease to decipher genomic regulatory networks. AI/ML offers multiple supervised and unsupervised approaches to analyze genomics data. Hence, AI and ML make prediction and analysis of gene expression data easier, thereby reducing manual errors. Furthermore, AI analyzes patients’ genomic data to identify mutations, variations, and biomarkers associated with different diseases. Thus, AI simplifies the gene expression analysis resulting in precise outcomes.

For instance,

  • In August 2023, researchers from the University of Toronto developed a novel AI model called single-cell generative pre-trained transformer (scGPT) to identify cell types, predict the effects of disrupting genes, and pinpoint which genes interact.

Market Dynamics

Driver

Rising Incidences of Cancer

Cancer is the most prevalent chronic disorder and the leading cause of death globally. The rising incidences of cancer worldwide promote the gene expression market. Genes play a vital role in cancer. Genes are turned on and off in normal cells, whereas this process is misregulated in tumor cells, leading to cancer. Several researchers are investigating the correlation between drug sensitivities and gene expression or mutations. Identifying gene expression patterns in patients with tumors can provide ideas about disease mechanisms and progression as well as help in developing novel drug candidates based on these gene expression patterns. Novel treatment strategies are developed to block deleterious gene expression. Thus, the rising incidences of cancer lead to increased applications of gene expressions, thereby promoting market growth.

Cancer Cases (In Millions)

Restraint

RNA Quality Issues and High Cost

The major challenge of the gene expression market is the RNA quality issues. RNA is less stable than DNA and care should be taken and adequate protocols followed to preserve the quality of biological material. This technical difficulty may restrict market growth. Furthermore, the high cost of gene expression analysis services limits the affordability of numerous researchers, especially in low- and middle-income countries.

Opportunity

Growing Research and Development Activities

The growing research and development activities involving gene expression methods create ample opportunities for the gene expression market players over the coming years. Recent advancements are driven by increasing genomics and proteomics research. Gene expression has widespread applications in every aspect of biotechnology from agriculture to medicine. It is used to identify disease progression and develop novel therapeutic agents. The growing demand for personalized therapy also augments the demand for gene expression analysis. Technological advancements in various techniques like western blot, ELISA, fluorescence in situ hybridization, and many more have led to advancements in research methodologies. The growing research and development activities are also governed by increasing collaborations between research organizations.

Segmental Insights

cDNA Synthesis and Conversion Segment Dominated

By process, the cDNA synthesis and conversion segment held a dominant presence in the gene expression market in 2023. cDNA synthesis is a process used to synthesize complementary DNA (cDNA) using an RNA template and reverse transcriptase enzyme. It is widely used in gene expression studies. The synthesis of high-quality cDNA, that precisely reflects the RNA of interest, must be produced before qPCR analysis can proceed for gene expression to be successful. The widespread availability of process reagents and kits for cDNA synthesis and conversion augments the segment’s growth.

Data Analysis and Interpretation Segment: Fastest-Growing

By process, the data analysis and interpretation segment is expected to grow at the fastest rate in the market during the forecast period. The information encoded in a gene is interpreted to create a function. The segment’s growth is attributed to the availability of a wide range of methods for visualizing and interpreting gene expression data including heatmaps and clustering, gene set enrichment analysis and pathway analysis, and network analysis.

Kits & Reagents Segment Led in 2023

By product, kits & reagents segment led the global gene expression market in 2023. The kits & reagents are easily available from several market players, facilitating researchers to perform gene expression studies numerous times and get reproducible results at affordable prices.

DNA Chips Segment: Fastest-Growing

By product, the DNA chips segment is anticipated to grow with the highest CAGR in the market during the studied years. DNA chips or DNA microarrays measure the expression levels of a large number of genes simultaneously. They are used in clinical diagnostic tests as well as to determine which drugs might be best prescribed for particular individuals. Their demand is increasing due to diverse applications in disease identification and treatment.

High-Plex Segment Held the Largest Share

By capacity, the high-plex segment held the largest share of the gene expression market in 2023. High-plex gene expression is a technique that allows for the measurement of hundreds or thousands of genes simultaneously per cell, allowing researchers to find the best markers for different cell types. Additionally, high-plex gene expression allows deeper characterization of how cells connect and communicate. It can overcome several challenges of low-plex gene expression. The technique is simple, accurate, and reduces hands-on time, compared to other conventional techniques.

Low- to Mid-Plex Segment: Significantly Growing

By capacity, the low- to mid-plex segment is predicted to witness significant growth in the market over the forecast period. Low- to mid-plex gene expression was used traditionally to analyze a limited number of genes from 5-500 targets. They are cost-effective and easy to perform.

Drug Discovery & Development Segment Dominated

By application, the drug discovery & development segment registered its dominance over the global gene expression market in 2023. The rising incidences of chronic disorders globally owing to rising population and sedentary lifestyles have led to novel drug discovery and development. Gene expression analysis gives a deeper understanding of the genes and proteins involved in the disease and responsible for causing the disease, aiding in the development of novel drugs. The growing research and development activities and new product launches potentiate the segment’s growth.

Clinical Diagnostics Segment: Fastest-Growing

By application, the clinical diagnostics segment is projected to expand rapidly in the market in the coming years. The rising incidences and prevalence of chronic disorders necessitate the development of clinical diagnostics. The availability of vast amounts of data on gene expression presents the opportunity to understand disease mechanisms and identify molecular markers for more precise diagnosis and the prediction of prognosis and treatment response.

RNA Expression Segment Dominated

By technique, the RNA expression segment dominated the gene expression market in 2023 globally. RNA sequencing is a technique to examine the quantity and sequences of RNA in a sample using next-generation sequencing. It aids in understanding the biology of a cell and assessing changes that may indicate disease. It is used to identify disease biomarkers, identify different cell types in the brain, and study pathogen-host interactions.

Promoter Analysis Segment: Fastest-Growing

By technique, the promoter analysis segment is estimated to show the fastest growth over the forecast period. Promoter analysis can be done by analyzing the expression levels of RNA. It is used to identify the major factors that govern genetic activity. The first step in gene transcription is to find the promoter region in the DNA sequence.

Regional Insights

Increasing Investments Dominated North America

North America held the major share of the gene expression market in 2023. The rising incidences of chronic disorders, technological advancements, state-of-the-art research and development facilities, and increasing investments drive the market. The National Institute of Health, the National Human Genome Research Institute (NHGRI), and Health Canada are some of the government organizations that provide funding for gene expression research. Genome Canada announced $18.1 million for 13 late-stage R&D projects tackling major challenges in health, environment, and agriculture through genomics in 2023. The market is also driven by the presence of key players such as Thermo Fisher Scientific, Bio-Rad Laboratories, Promega Corporation, etc.

In February 2024, the US National Science Foundation awarded around $12.7 million to nine research teams to seek a new understanding of the inner functions and potential uses of intricate RNA functions for a wide range of applications from disease prevention in crops to cancer-fighting therapies.

NHGRI Proposed Budget, 2024 (In Million Dollars)

Favorable Government Support to Promote Asia-Pacific

Asia-Pacific is projected to host the fastest-growing gene expression market in the coming years. The rising incidences and prevalence of chronic disorders, increasing adoption of advanced technologies, growing research and development activities, and favorable government support drive the market. Several government organizations from China, India, and Japan support genomics and proteomics research and personalized medicines through releasing guidelines and initiatives and providing funding.

In July 2024, China’s Ministry of Science and Technology launched a new set of Ethical Guidelines for Human Genome Editing for the regulation of genetic research in the country.

Additionally, the burgeoning biotechnology and biopharmaceutical sectors in the region boost market growth. The appropriate training and expertise is provided by organizing various symposiums, workshops, and conferences in the region.

Top Companies in the Gene Expression Market

  • Biomarker Pharmaceuticals
  • Bio-Rad Laboratories
  • Creative Biogene
  • LogicBio Therapeutics
  • NanoString Technologies
  • Ocean Genomics
  • Promega Corp
  • Qiagen
  • Quest Diagnostics
  • Reprocell
  • Syros Pharmaceuticals
  • Tierra Biosciences
  • Thermo Fisher Scientific

Gene Expression Market Companies

Latest Announcement by Industry Leaders

Dr. Kärt Tomberg, CEO and Co-Founder of ExpressionEdits, commented on its recent fundraising that the company is revolutionizing gene expression by putting introns back where they belong, resulting in significant improvements in production. He added that the company’s AI platform empowers precise decisions about introns to unlock unprecedented protein expression levels. He also shared that the company’s mission is to be pioneers in making protein therapeutics readily available and accessible to patients.

Recent Developments in the Gene Expression Market

  • In October 2024, researchers from Jackson Laboratory, Broad Institute of MIT and Harvard, and Yale University, developed an AI model, allowing precise activation or repression of genes in specific tissues, to design thousands of new DNA switches that can precisely control the expression of a gene in different cell types.
  • In August 2024, researchers from Northwestern University discovered that interactions between RNA and the TOP1 enzyme regulate DNA during transcription and may inform the creation of new cancer therapies.

Segments Covered in the Report

By Process

  • cDNA Synthesis and Conversion
  • Data Analysis and Interpretation
  • Sample Collection
  • Purification
  • PCR Analysis

By Product

  • Kits & Reagents
  • DNA Chips
  • Others

By Capacity

  • High-Plex
  • Low- to Mid-Plex

By Application

  • Drug Discovery & Development
  • Clinical Diagnostics
  • Biotech & Microbiology
  • Others

By Technique

  • RNA Expression
  • Promoter Analysis
  • Protein Expression & Posttranslational Modification Analysis

By Region

  • North America
    • US
    • Canada
  • Asia Pacific
    • China
    • Japan
    • India
    • South Korea
    • Thailand
  • Europe
    • Germany
    • UK
    • France
    • Italy
    • Spain
    • Sweden
    • Denmark
    • Norway
  • Latin America
    • Brazil
    • Mexico
    • Argentina
  • Middle East and Africa (MEA)
    • South Africa
    • UAE
    • Saudi Arabia
    • Kuwait
  • Insight Code: 5380
  • No. of Pages: 150+
  • Format: PDF/PPT/Excel
  • Published: December 2024
  • Report Covered: [Revenue + Volume]
  • Historical Year: 2021-2022
  • Base Year: 2023
  • Estimated Years: 2024-2033

Meet the Team

Rohan Patil is a market research expert with 5+ years of experience in healthcare, specializing in market dynamics, emerging trends, and technology-driven innovations to guide data-driven decisions for healthcare organizations.

Learn more about Rohan Patil

Aditi Shivarkar, with 14+ years of healthcare market research experience, ensures the accuracy, clarity, and relevance of reports. Her expertise helps businesses make informed decisions and stay competitive in healthcare sectors.

Learn more about Aditi Shivarkar

Related Reports

FAQ's

Gender is the major internal environmental factor, as well as drugs, chemicals, temperature, and light, are external environmental factors that interfere with gene expression and influence the way an organism develops and functions.

The regulation of gene expression requires energy and space, so it is more energy-efficient to turn on the genes only when they are required.

National Human Genome Research Institute, World Health Organization, National Institute of Health.