September 2024
The global gene synthesis market size was estimated at US$ 2.1 billion in 2023 and is projected to grow US$ 9.38 billion by 2033, rising at a compound annual growth rate (CAGR) of 16.14% from 2024 to 2033. The growing demand for gene therapy and personalized treatments boosts the demand for gene synthesis.
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Gene synthesis is a dependable and economical technique that yields 100% sequence correctness in bespoke DNA constructs. DNA synthesis is a potent molecular biology method that has revolutionized modern biology and is quickly emerging as an essential component of the research workflow. Gene synthesis is often used in research and development projects in a variety of industries. The gene synthesis market has grown as a result of the growing uses of synthetic biology. Gene synthesis services are being outsourced to specialized organizations by a large number of university and research institutions, small biotech startups and firms. The market for gene synthesis has drawn large governmental and private investments. Gene synthesis infrastructure and technologies are receiving significant funding from governments, universities, and biotechnology corporations. Funding and research grants have made it easier to produce new products and upgrade technology, which has increased gene synthesis market growth.
| Company Name | Twist Bioscience |
| Headquarters | California, U.S. |
| Pipeline | In January 2024, high-quality synthetic DNA may be supplied to consumers by Twist Bioscience Corporation thanks to its silicon platform. Today, the business said that bigger DNA preparations up to 1 milligram would now be available through Twist Express Genes, a new, industry-leading gene synthesis service. It will take five business days to complete shipping orders. |
| Company Name | Integrated DNA Technologies Inc. |
| Headquarters | Lowa, U.S. |
| Pipeline | In March 2024, Integrated DNA Technologies (IDT), a global provider of genomics solutions, is adding a new bespoke vector onboarding tool to its gene synthesis capabilities. Researchers who wish to expedite functional investigations with 100% sequence-verified clonal DNA and avoid internal cloning processes can utilize this user-friendly approach. Researchers may submit their vector sequence via IDT's website without needing to get in touch with a salesperson by utilizing the company's new gene synthesis custom vector onboarding tool. This eliminates needless back-and-forth communications. |
Gene synthesis has made an incredible contribution to the quickly changing field of drug research, from the creation of vaccines to new therapeutic targets to biologics. Biology research has been changed by gene synthesis technology. Scientists may now design or reprogram entire genomes and cells rather than being restricted to the traditional techniques of modifying one gene at a time. Technologies and methods for synthesizing DNA are rapidly establishing themselves as essential components of contemporary molecular biology and are essential to the study of synthetic biology. It is no longer an idea that complete genes, new genetic pathways, or even entire genomes may be synthesized.
The ethical considerations surrounding the use of gene drives and genetic engineering in conservation are often categorized as including risk assessment and management, opportunity costs, risk and benefit distributions, public acceptability and participation, and oversight. Although they are crucial, the ethical issues go beyond them since genetic engineering has the ability to drastically change the beliefs, methods, and values associated with conservation.
There are now a lot of novel genetic illnesses being reported in the medical literature, in addition to the well over 6,000 established genetic disorders. There are several uncommon genetic diseases that have received far less attention and may not have been properly identified. Numerous substances found in both artificial and natural surroundings have the potential to damage a person's DNA. These agents may include alcohol, combustion products, viruses, and substances produced by fungi, bacteria, or plants; they may also include industrial chemicals, oxygen, UV and ionizing radiation, and combustion products. Owing to the extended half-lives of many of these substances, humans have developed defensive mechanisms to mitigate their negative effects as well as methods for repairing the harm that cannot be prevented. A multitude of variables are driving up the incidence of genetic abnormalities, which in turn is driving up demand for gene synthesis.
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By method, the solid-phase synthesis segment held the largest gene synthesis market share in 2023. Combinatorial chemistry, oligonucleotide, oligosaccharide, and peptide synthesis all make extensive use of solid-phase synthesis. Solid-phase synthesis offers several benefits for creating intricate peptide-based macrocycles. Easy purification, quick production of linear peptide intermediates, and experience with large-scale peptide synthesis are the general benefits of solid-phase synthesis. Simple equipment, ease of use, a single synthesis process, uniform and controllable particle sizes, minimal pollution, and the ability to prevent or lessen the hard agglomeration phenomenon—which is easily observed in the liquid phase—are just a few of the solid phase synthesis method's many notable benefits. Its cost is also cheap.
By service, the antibody DNA synthesis segment dominated the gene synthesis market in 2023. Various modified antibody molecules for study, diagnosis, and therapy have been developed as a result of advancements in recombinant monoclonal antibody (rAb) technology. A number of laborious processes are involved in developing antibody therapies, such as generating lead candidate genes, cloning them into vectors, and amplifying plasmids in Escherichia coli cells. The effective in vitro production of synthetic DNA products has been made possible by recent advancements in synthetic biology and automation. Recombinant antibodies (rAbs) have a wide range of uses in toxicological and biological research. Recombinant monoclonal antibodies are frequently employed as biochemical indicators and diagnostic instruments or in the development of potent therapeutic interventions that target autoimmune diseases, cancer, and a wide range of other illnesses.
By service, the viral DNA synthesis segment is estimated to grow at the fastest rate during the forecast period. The ability to chemically synthesize viral genomes offers researchers a novel and potent tool for examining the expression, function, and pathogenic potential of viral genes. If there's no natural viral template available, this approach comes in quite handy. On a scale that would be hard to do with traditional molecular biology techniques, it also permits the genetic manipulation of viral genomes.
By application, the gene & cell therapy development segment held the largest share of the gene synthesis market in 2023. Because genes may be artificially created for insertion or replacement, gene synthesis has the potential to completely transform the way tailored medications are administered. Patient care may be completely transformed by personalized medication. Using pharmacogenetic and pharmacogenomic data, this therapeutic approach recommends medications tailored to each patient. The foundation for a system that potentially helps millions of people is being laid by innovations in customized healthcare. Patient-centered best practices, actionable precision diagnostics, and effective precision therapy must be combined to scale personalized care to a more accessible and standardized level.
By region, North America dominated the gene synthesis market in 2023. North America has a reputation for leading the market in the area when it comes to technical developments, research, and development. The market is growing at a large rate because of nations like the United States and Canada. Genetic problems are becoming more common and need both gene synthesis and gene therapy.
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With about 40% of the worldwide synthetic biology business, the U.S. leads the world in this field. Due to this, the U.S. is in a strong position to establish industry standards, therefore raising the bar for acceptable practice and holding businesses accountable for negligence if they fall short of it. Due to its market dominance, the U.S. is able to take the initiative that ought to inspire other nations with developing synthetic biology businesses to follow suit. Companies that produce synthetic DNA have a strong incentive to make sure they can meet the demand for their product since the U.S. government is a major sponsor of life sciences research.
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By region, Asia Pacific is estimated to grow with the fastest CAGR during the forecast period. The market for gene synthesis is growing at a rapid rate, and the largest region is Asia Pacific. The market is expanding as a result of nations like South Korea, China, Japan, and India. These nations are demonstrating government investment in biotechnology, genetic engineering, agriculture, and healthcare, as well as technical advancements.
India is one of the top 5 economies in the world and a major contributor to biotechnology and gene synthesis. The Indian government has launched a number of projects that support the expansion of the sector. The prevalence of genetic illnesses is rising in India as well, and gene synthesis will be necessary for both diagnosis and therapy. Rare genetic illnesses have gradually gained more attention in India in recent years, drawing the interest of researchers, medical professionals, and decision-makers.
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Deepa has certified the degree of Master’s in Pharmacy in the Pharmaceutical Quality Assurance department from Dr D.Y. Patil College of Pharmacy. Her research is focused on the healthcare industry. She is the author or co-author of four Review Articles, which include Solid dispersion a strategic method for poorly soluble drugs and solubility improvement techniques for poorly soluble drugs, Herbal Drugs Used In Treatment Of Cataracts, Nano sponges And Their Application in Cancer Prevention and Ayurvedic Remedies of Peptic ulcer. She has also published a Research Article on the Formulation and Evaluation of Mucoadhesive Tablets of Miconazole cocrystal which was published in GIS Science Journal Volume 9 Issue 8. Her passion for secondary research and desire to take on the challenge of solving unresolved issues is making her flourish is the in the research sector.