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November 2024
The global resorbable nerve conduits market size was estimated at US$ 2.31 billion in 2023 and is projected to grow to US$ 5.28 billion by 2034, rising at a compound annual growth rate (CAGR) of 7.8% from 2024 to 2034. The rising demand to treat nerve injuries by reducing the risk of inflammation and regenerating nerve with the presence of foreign body is increasing the adoption of resorbable nerve conduit market.
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Resorbable nerve conduit devices may be derived from natural or synthetic materials. Utilization of a resorbable PGA (polyglycolic acid) tube filled with collagen sponge restores both sensory and motor electrophysiological functions. This technique is also considered superior to an autograft technique. The combination of a resorbable synthetic tube with biological factors leads the way in advancing the future. This strategy encourages and hastens nerve growth. The incorporation of several neurotrophic factors has demonstrated the capability to promote axonal growth in vitro. However, its use in vivo is still undiscovered.
The potential of artificial intelligence (AI) in the production of resorbable nerve conduits is well-known. AI and machine learning (ML) algorithms aid in the large-scale manufacturing of nerve conduits. They also revolutionize the research and development process by analyzing the effect of resorbable nerve conduits in humans on a prior basis. AI can also predict the type and combination of materials used to prepare nerve conduits. Advanced technologies such as 3D and 4D printing technologies use AI and ML algorithms to produce customizable products. They also help to produce cost-effective products and automate the manufacturing process, eliminating manual errors. Hence, leveraging these technologies, the developed nerve conduits demonstrate remarkable potential in promoting peripheral nerve regeneration.
The rising incidences of peripheral nervous system disorders increase the demand for effective treatment regimens. The availability of multiple natural and synthetic materials facilitates the development of resorbable nerve conduits. Researchers have investigated the role of cell-based therapies such as stem cells in nerve conduits. It has been found that stem cells can differentiate into nerve cells, promoting nerve regeneration and potentially relieving neuropathic symptoms. Numerous studies have shown positive results of stem cells-induced resorbable nerve conduits for axonal regeneration and functional recovery during pre-clinical experiments. The demand for stem cells is also rising due to favorable government policies and increasing investments for promoting and conducting stem cell research.
The innovation of biodegradable nanomaterial is expected to be beneficial for manufacturing new nerve conduits. Combining an adequate density and 3D structure to design a scaffold with Schwann Cells can replicate Bands of Büngner to enhance the regrowth of axons in the peripheral nerve injury. To eliminate the immune rejection. Schwann Cells can be withdrawn from either umbilical stem cells or other tissues such as autologous adipose tissue. This collaboration application of tissue, cell and genetic engineering can provide promising results in better functional recovery of peripheral nerve injury.
The clinical potential of nerve conduit technology needs a strategic design, biomaterial selection, fabrication technique and modification to create a microenvironment to mimic the natural process of regeneration. There has been a significant process in designing and functionality of bioengineered nerve conduits to bridge long peripheral nerve gaps. However, implementation of the same strategy into a commercial scale has not been achieve yet. This area requires special attention which slowing down the market growth.
North America dominated the resorbable nerve conduit market in 2023. The dominance of this region is attributed to the strong presence of major companies in North America. The companies had increased in manufacturing of novel nerve repair products. The United States-based private medical companies are focusing on developing more advanced mineral and collagen-based medical devices to regenerate naturally.
Consistent development in innovative techniques and devices such as nerve conduits, neurostimulation devices and bioengineered material resulting in improved nerve injury treatment is observed by key players of the market including Axogen, Integra Lifesciences, Boston Scientific Corp., Medtronic, Baxter, Regenity Bioscience and many more.
Asia Pacific is expected to grow at the fastest rate over the forecast period. The growth in this region is noticed by the rising awareness about nerve repair treatment and surgeries and progress in the Research and Development team. Peripheral nerve repair and regeneration awareness is particularly observed in countries such as China, Japan, and South Korea. Increasing demand for neurological products and the prevalence of neurological disorders is encouraging the R&D team to progress.
By material, the synthetic polymer segment dominated the resorbable nerve conduits market in 2023. The dominance is observed due to the advantages offered by synthetic material in the fabrication of the device for peripheral nerve injury. The readily availability and engineered to modify its physical and mechanical characteristics such as strength, permeability and degradation rate promotes growth in the market.
The natural polymer segment is observed to be the fastest-growing in the resorbable nerve conduits market during the forecast period. The growth of this segment is due to the mitigation of the second surgery needed to remove the implant and prevent the long-term compression of the nerve. Some commonly used natural polymers are laminin, fibronectin, and collagen.
By application, the peripheral nerve repair segment led the resorbable nerve conduit market in 2023. This dominance is noticed due to the segment’s popularity in to use of resorbable nerve conduits. The nerve conduit aids in bridging gaps in peripheral nerves. This is easy to apply and does not require a donor site.
The spinal cord repair segment shows a notable growth in the resorbable nerve conduits market during the forecast period. Spinal cord injuries are repaired by guiding axonal regeneration and creating a protective environment for neurons. With the help of prostheses and medicines, researchers are promoting nerve cell regeneration and improving the function of the nerve that remains after a spinal cord injury.
By conduit design, the multi-lumen conduits segment dominated the resorbable nerve conduits market in 2023. Multi-lumen conduits promote regeneration of peripheral nerve by biding a 10 mm gap. During the regeneration process multi-lumen conduit can control the release of neurotrophic factors. The use of multi-lumen conduit is more advantageous over others due to its better mimic of natural structure.
The branch conduit segment is observed to be the fastest-growing in the resorbable nerve conduits market during the forecast period. The growth is noticed as branch nerve conduit can be customized by 3D printing technology. This offers the desired shape and addition of active cells.
By mechanism of action, the neurotrophic conduit segment dominated the resorbable nerve conduits market by holding the largest market share. Neurotrophic factors are polypeptide systems that support cell survival. It also acts upon motor and sensory neuron regeneration both in vivo and in vitro.
The Glial conduit segment is anticipated to grow at the fastest rate in the resorbable nerve conduits market over the projected period. The growth of this segment is linked with the regeneration of axons by providing a supportive environment.
By regeneration level, the complete regeneration segment accounted for the largest share of the resorbable serve conduits market in 2023. The segment is dominated by successful recovery of nerve injury by increasing the adoption of advanced nerve repair techniques. Regaining the sensory functions and movement claims for complete recovery of regeneration.
The partial regeneration segment is anticipated to witness significant growth in the resorbable nerve conduits market over the studied period. Partial regeneration is encountered by the slow recovery of the injured nerve when the recovery rate is 1 millimetre per day and 1 inch per month. Slow recovery leads to unsatisfactory patients.
By Material
By Application
By Conduit Design
By Mechanism of Action
By Regeneration Level
By Region
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