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December 2024
The global sequencing market size was estimated at US$ 15.59 billion in 2023 and is projected to grow US$ 115.85 billion by 2033, rising at a compound annual growth rate (CAGR) of 22.21% from 2024 to 2033. The market is witnessing rapid growth due to increased applications in different industries.
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The sequencing market encompasses all the resources, including reagents & kits, equipment, evidence, professionals, etc, for sequencing of DNA, RNA, and protein. In the sequencing process, the sequence of nucleotides in DNA and RNA and the sequence of amino acids in a protein are determined with the help of different tools and techniques. With the use of sequencing data, scientists can find variations in genes and noncoding DNA (such as regulatory sequences), correlations with phenotypes and illnesses, and possible targets for future medications. Numerous fields, including the study of diseases, developmental biology, epigenetics, evolution, genetic relationships between various species, the creation of genetically engineered organisms and vaccines, and disease research, have benefited greatly from sequencing. The sequencing market has a lot of room to develop in the future because of rising technology, rising food consumption and rising healthcare sector demand brought on by the rising incidence of chronic illnesses.
| Company Name | Illumina Inc. |
| Headquarters | California, U.S. |
| Pipeline | A fast, repeatable, and scalable whole-genome sequencing process in 2024. In order to increase speed, reproducibility, and scalability to provide rWGS of 13.5 hours, Illumina is studying and developing a new, reengineered genome sequencing methodology. With the help of Illumina's next-generation sequencing (NGS) technology, this pipeline—which was created in partnership with Rady Children's Institute for Genomic Medicine—eliminates crucial bottlenecks in traditional rWGS workflows by streamlining variant calling, sequencing, and library preparation for quick and precise identification of genetic variants, including complex structural variation. |
| Company Name | PacBio |
| Headquarters | California, U.S. |
| Pipeline | In October 2023, PacBio WGS Variant Pipeline, a full, standardized computational technique for HiFi whole genome sequencing (WGS) data interpretation, was made available. PacBio is a leading producer of high-quality, highly accurate sequencing products. Customers will be able to resolve a wide variety of variant types using the new software pipeline, which makes it the most comprehensive human WGS secondary analysis process out there. |
Because there are more and more genetic problems, gene therapy is one of the medical specialties that is expanding the quickest. Gene therapies are a promising class of treatments that can be used to treat a wide range of diseases; their goal is to treat the underlying causes of the diseases rather than just their symptoms. Numerous illnesses that were previously incurable, including cancer and neurological and hematological disorders, may respond well to them. Gene treatments are thought to have the potential to revolutionize the pharmaceutical and health sciences. Globally, there are more and more clinical studies looking at gene therapy.
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Traditional notions of informed consent are called into question, and privacy and security concerns are heightened by the growing collection and use of private medical and biological data, such as that needed for genomics research. Importantly, new problems will come up since a big and diversified collection of genetic information is necessary for an efficient genomic service. There may be worries expressed about the possibility of major privacy violations from unintentional data releases or illegal activities like hacking or data theft. Without an express agreement, it is morally acceptable to regularly collect, store, and connect genetic data to be kept in healthcare service records. Authorized access to data should also be promoted.
Advanced computing and inference techniques used by AI give insights that improve medical decision-making by allowing the system to reason and learn. Cell properties that may be evaluated at high throughput and utilized as training targets for predictive models include splicing, protein binding to nucleic acids and gene up-regulation. The enhanced accessibility of a wide range of information and contemporary computer methods like machine learning can help researchers usher in a new era of efficient genomic medicine.
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By product & service, the consumables segment dominated the sequencing market in 2023. From straightforward procedures and materials for DNA cloning, molecular biology kits have developed into more sophisticated sets of reagents that allow for whole genome sequencing. These days, kits may be obtained anywhere—from the home medicine cabinet to the doctor's office. They are no longer limited to the lab. The offspring of lab kits from bygone eras, as well as over-the-counter home tests, come in various forms, including DNA testing. Even now, the reagents and kits are showing up online. Additionally, kits for RNAi, quantitative PCR, rapid PCR, long-range PCR, genotyping, and other techniques that expedite research or simplify lab life are in great demand. These days, kits constitute a crucial component of many biological instruments.
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By workflow, the sequencing segment dominated the sequencing market in 2023. Throughout the previous 20 years, there has been a noticeable advancement in genome sequencing technology in terms of cost and time. Now, a new single-molecule sequencing method called third-generation sequencing is being developed. These strategies have been developed to lower sequencing costs and automate preprocessing and sequencing operations. Exciting developments and new findings in a variety of academic domains will be provided by sequencing in the future. Improvements to diagnostic techniques are made possible by the steady rise of sequencing technology. Enhancing productivity and accuracy while cutting down on processing time will be the future objectives of researchers. Scientists utilize the information gathered from sequencing to create novel prognostic and diagnostic approaches.
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By workflow, the data analysis segment is expected to witness the fastest growth during the forecast period. Large amounts of data are produced by sequencing, and the necessary analysis might be frightening. Thankfully, the majority of the manual labor involved in the NGS data processing process is eliminated by the analytical tools that are already on the market, making it simpler for you to obtain important information quickly. Primary, secondary, and tertiary data analysis are the three key processes in the NGS data analysis process. Certain actions are carried out automatically by the sequencing device, and other actions take place once the sequencing process is finished. An important phase in biological research that involves processing and interpreting large amounts of data obtained from biological specimens is known as genomic data analysis.
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By application, the oncology segment dominated the sequencing market in 2023. The development, control, and progression of cancer have become better understood because of NGS-based cancer sequencing techniques, which have also opened up new research avenues. These methods aid in the identification of genomic alterations in cancer and their effects on the transcriptome, epigenome, and proteome. NGS significantly increases the possibility of the discovery of each sample by evaluating hundreds of targets simultaneously. Additionally, low-frequency molecular events linked to cancer development, metastasis, and carcinogenesis that may go undetected by conventional molecular techniques can be found by NGS. When taken as a whole, these developments are opening the door to better translational medicine and therapeutics in the future. With the growing prevalence of cases of cancer, the need for sequencing will grow continuously.
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By application, the consumer genomics segment is expected to witness the fastest growth during the forecast period. By 2022, it is expected to have increased by a factor of ten, reaching up to 100 million genotyped people. The growth rate is probably going to outpace these estimates due to lower costs associated with genotyping and sequencing as well as more promotional expenditure from industry leaders. More businesses will join the genomics direct-to-consumer (retail) industry in the upcoming years. Greater innovation and insight will be possible as a result of the large returns on scale that these enormous numbers of genotyped customers will produce. Large sample numbers provide increased statistical power to identify connections across the genome, which might be helpful in establishing a connection between functional qualities, clinical symptoms, and genetic markers.
By region, North America dominated the sequencing market in 2023 due to the leading industry competitors' continuous technical developments. The region's genome sequencing market is expected to rise due in part to the substantial investments made in research and development as well as the high accessibility of scientifically established healthcare infrastructure. The countries that majorly contribute to the market growth in the region are the U.S. and Canada.
The AMD initiative hires bioinformatics experts, trains public health personnel in the U.S., and deploys next-generation sequencing tools at the CDC and in state and local health agencies. The AMD program contributes to the development and integration of epidemiology, bioinformatics, and laboratory technologies inside the CDC as well as in state and local public health systems. In order to create and test next-generation diagnostics and procedures with and for the CDC as well as state, municipal, and public health laboratories, the AMD program supports other initiatives within the agency.
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By region, Asia Pacific is expected to witness the fastest growth during the forecast period. The sequencing market is anticipated to be driven by the existence of regional businesses like BGI Genomics and NGS service providers like First BASE Laboratories Sdn Bhd, Macrogen Asia-Pacific Pte Ltd., and others. Countries like India, China, Japan, and South Korea contribute to the growth.
There are about 4,600 different demographic groupings in India, home to 1.3 billion people, many of whom practice endogamy. The current population's genetic diversity is a result of these influences. As a result, there are many different variances in the Indian population, and numerous disease-causing mutations are frequently magnified among certain of these groups. In February 2024, the Department of Biotechnology (DBT) declared the final conclusion of the "10,000 genomes" initiative, which aimed to establish an Indian whole-genome sequencing reference database.
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